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Zepbound® : A New Option for Weight Management

Zepbound®  is a prescription medication approved by the FDA to help adults with obesity—or those who are overweight and have related health concerns—lose weight more effectively. It functions by mimicking gut hormones that impact hunger and fullness, helping regulate appetite and blood sugar. When combined with healthy eating and increased activity, patients may lose up to 20% of their body weight.*

At Genesis Lifestyle Medicine in Fishers, we’ll assess your individual health profile to determine if Zepbound is right for your journey.

What Are the Benefits of Zepbound?

Zepbound may offer multiple health benefits when used under medical supervision:

  • May reduce appetite and food cravings
  • Can support long-term weight loss efforts
  • Helps the body better manage blood sugar levels
  • Increases the feeling of fullness after meals
  • Works on multiple hormone pathways for a metabolic boost
  • Shown in clinical trials to promote significant weight loss
  • FDA-approved for qualifying patients
  • Weekly injection using a prefilled pen
  • Administered with support from licensed medical providers
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Possible Side Effects

As with any prescription medication, Zepbound can cause side effects. Some patients may experience:

  • Nausea or vomiting
  • Diarrhea or constipation
  • Abdominal pain or indigestion
  • Tiredness or drowsiness
  • Reactions at the injection site
  • Heartburn, gas, or mild hair thinning
  • Allergic responses

Zepbound is not suitable for those with a personal or family history of medullary thyroid carcinoma (MTC) or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). For detailed safety guidelines, please visit Lilly’s official site.

How Zepbound May Aid in Weight Loss

Zepbound mimics two natural gut hormones—GLP-1 and GIP—which play important roles in regulating hunger and blood sugar. These hormones send signals to the brain that reduce appetite, slow digestion, and increase satisfaction after eating.

By targeting these hormonal pathways, Zepbound may help you feel full sooner and avoid overeating, making it easier to manage calorie intake. Additionally, it may assist in stabilizing blood sugar levels, which is especially useful for individuals dealing with insulin resistance or prediabetes.

What to Expect During Treatment

Your Zepbound program at our Fishers clinic begins with a face-to-face consultation. Our medical team will review your medical background, perform lab testing if needed, and discuss your weight loss history and goals.

If Zepbound is prescribed, we’ll show you how to self-administer it using a user-friendly prefilled injector pen. Injections are done weekly, usually in the thigh or abdomen. Your dosage will be carefully adjusted over time based on your body’s response, all under close medical guidance to minimize side effects and maximize effectiveness.

Insurance and Coverage

Insurance coverage for Zepbound differs depending on the provider and plan. Some commercial insurance policies may cover the medication, often requiring prior authorization. Medicare may also cover Zepbound in certain circumstances. Our team can assist in exploring your coverage options and help with any required paperwork.

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Are You a Good Candidate?

You may qualify for Zepbound treatment in Fishers if:

  • Your BMI is 30 or greater (obesity)
  • Your BMI is 27 or greater and you have a related condition like type 2 diabetes or high blood pressure
  • You’ve had difficulty losing weight through diet and exercise alone
  • You’re looking for a non-surgical weight loss alternative
  • You’re ready to make meaningful changes to your lifestyle
  • You don’t have a history of certain thyroid conditions like MTC or MEN 2

How Much Weight Could You Lose?

In clinical research, participants using Zepbound experienced notable weight loss over 72 weeks when combined with dietary changes and increased activity:

  • 5 mg dose: ~15% body weight lost (~34 lbs)
  • 10 mg dose: ~19.5% (~44 lbs)
  • 15 mg dose: ~20.9% (~48 lbs)
  • Placebo group: ~3.1% (~7 lbs)*
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Zepbound FAQs

When will I start seeing results?

Some patients begin to notice weight changes in the first few weeks. More substantial progress is typically seen after 2–3 months when used consistently with diet and exercise.

Is Zepbound safe to use?

Zepbound is FDA-approved and has undergone extensive clinical testing. Still, like any medication, it may cause side effects. Our medical professionals will monitor your progress closely and adjust your plan if needed.

How is Zepbound taken?

It is injected once weekly using a prefilled pen. Sites are rotated between the upper arm, thigh, or abdomen.

What if I forget a dose?

Take the missed dose within four days. If more than four days have passed, skip the missed dose and resume your schedule as normal. Never take two doses within three days.

Book a Zepbound Consultation in Fishers

At Genesis Lifestyle Medicine in Fishers, our goal is to help you feel your best—inside and out. Zepbound is just one of the tools we may use in a comprehensive, medically supervised weight loss plan. If you're ready to explore whether this option is right for you, schedule your in-person consultation today.

*Individual results vary. In a 72-week Zepbound (tirzepatide) study of adults without diabetes, average weight loss was 15.0% (34 lbs.) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs.) for 15 mg, and 3.1% (7 lbs.) for placebo. In a 72-week Zepbound (tirzepatide) study of adults with diabetes, average weight loss was 12.8% (28 lbs.) for 10 mg, 14.7% (33 lbs.) for 15 mg, and 3.2% (7 lbs.) for placebo.

Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4. https://pubmed.ncbi.nlm.nih.gov/35658024

The information provided on this website is not a substitute for professional medical advice. Always consult with a qualified healthcare provider for any questions about your health or treatment.

Zepbound® is a registered trademark of Eli Lilly and Company. This website is not affiliated with, endorsed by, or sponsored by Eli Lilly and Company. All trademarks and brand names are property of their respective owners. Use of these names, logos, and brands does not imply endorsement Genesis Lifestyle Medicine. Information about Zepbound is sourced from publicly available materials and is intended for educational and informational purposes only. All rights to such content belong to the respective company.

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